Synthesis and fungicidal activity of novel 1,2,4-triazole derivatives containing a pyrimidine moiety
Wen-Neng Wu
Yang-Ming Jiang
Qiang- Fei
Hai-Tang Du
10.6084/m9.figshare.10011398.v1
https://tandf.figshare.com/articles/journal_contribution/Synthesis_and_fungicidal_activity_of_novel_1_2_4-triazole_derivatives_containing_a_pyrimidine_moiety/10011398
<p>A series of novel 1,2,4-triazole derivatives containing a pyrimidine moiety were synthesized and their fungicidal activities were evaluated. The preliminary biological test indicated that some of the target compounds exhibited moderate to good fungicidal activities against the tested plant pathogenic fungi compared with the commercial agent. Among them, compounds <b>9n</b> and <b>9o</b> exhibited excellent antifungal activity against <i>Phompsis</i> sp., with the half-maximal effective concentration (EC<sub>50</sub>) values of 25.4 and 31.6 μg/mL, which were even better than the commercial agent of Pyrimethanil (32.1 μg/mL). Meanwhile, compound <b>9o</b> showed better fungicidal activities against <i>B. dothidea</i> and <i>B. cinerea</i> with 40.1 and 55.1 μg/mL, respectively, in comparison with that of commercial Pyrimethanil (57.6 and 62.8 μg/mL).</p>
2019-10-22 07:10:42
Synthesis
1,2,4-triazole derivatives
pyrimidine
fungicidal activity