10.6084/m9.figshare.10758431.v1
Dafeng He
Dafeng
He
Rong Wang
Rong
Wang
Shaoshan Liang
Shaoshan
Liang
Dandan Liang
Dandan
Liang
Feng Xu
Feng
Xu
Caihong Zeng
Caihong
Zeng
Zheng Tang
Zheng
Tang
Comparison of secondary IgA nephropathy in patients with ankylosing spondylitis and rheumatoid arthritis
Taylor & Francis Group
2019
Ankylosing spondylitis
IgA nephropathy
HLA-B27
rheumatoid arthritis
clinic-pathology
2019-11-22 14:28:04
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Comparison_of_secondary_IgA_nephropathy_in_patients_with_ankylosing_spondylitis_and_rheumatoid_arthritis/10758431
<p><b>Objectives:</b> The aim of the present study was to investigate the differences in clinic-pathological features of secondary IgA nephropathy (SIgAN) between patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA).</p> <p><b>Methods:</b> Forty-six patients with SIgAN related to AS (SIgAN-AS) and 26 patients with SIgAN related to RA (SIgAN-RA) were enrolled in this retrospective study. The two groups were compared for their clinic-pathological characteristics.</p> <p><b>Results:</b> The 10-year prevalence of SIgAN-AS and SIgAN-RA were 167 per 1000 and 51.3 per 1000, respectively. Compared with SIgAN-RA patients, SIgAN-AS patients had lower incidences of edema and nephrotic syndrome, but higher levels of eGFR, serum C3, and CD3- and CD8-positive T-cell counts, but less incidences of acute tubulointerstitial lesions and interlobular arterial lesions. IgM was the most familiar co-depositing immune complex on tissue with significantly different frequencies. In SIgAN-AS patients, those with positive HLA-B27 presented with lower levels of proteinuria, higher levels of serum IgG and C3, and less incidence of renal insufficiency, crescents >14.5%, glomerular sclerosis >32.6% and segmental sclerosis >5.2%.</p> <p><b>Conclusion:</b> SIgAN was more prevalent in AS than in RA. SIgAN-AS patients differed from SIgAN-RA patients in certain clinic-pathological characteristics. HLA-B27 likely protected SIgAN-AS patients from renal insufficiency.</p>