10.6084/m9.figshare.10758431.v1 Dafeng He Dafeng He Rong Wang Rong Wang Shaoshan Liang Shaoshan Liang Dandan Liang Dandan Liang Feng Xu Feng Xu Caihong Zeng Caihong Zeng Zheng Tang Zheng Tang Comparison of secondary IgA nephropathy in patients with ankylosing spondylitis and rheumatoid arthritis Taylor & Francis Group 2019 Ankylosing spondylitis IgA nephropathy HLA-B27 rheumatoid arthritis clinic-pathology 2019-11-22 14:28:04 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Comparison_of_secondary_IgA_nephropathy_in_patients_with_ankylosing_spondylitis_and_rheumatoid_arthritis/10758431 <p><b>Objectives:</b> The aim of the present study was to investigate the differences in clinic-pathological features of secondary IgA nephropathy (SIgAN) between patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA).</p> <p><b>Methods:</b> Forty-six patients with SIgAN related to AS (SIgAN-AS) and 26 patients with SIgAN related to RA (SIgAN-RA) were enrolled in this retrospective study. The two groups were compared for their clinic-pathological characteristics.</p> <p><b>Results:</b> The 10-year prevalence of SIgAN-AS and SIgAN-RA were 167 per 1000 and 51.3 per 1000, respectively. Compared with SIgAN-RA patients, SIgAN-AS patients had lower incidences of edema and nephrotic syndrome, but higher levels of eGFR, serum C3, and CD3- and CD8-positive T-cell counts, but less incidences of acute tubulointerstitial lesions and interlobular arterial lesions. IgM was the most familiar co-depositing immune complex on tissue with significantly different frequencies. In SIgAN-AS patients, those with positive HLA-B27 presented with lower levels of proteinuria, higher levels of serum IgG and C3, and less incidence of renal insufficiency, crescents >14.5%, glomerular sclerosis >32.6% and segmental sclerosis >5.2%.</p> <p><b>Conclusion:</b> SIgAN was more prevalent in AS than in RA. SIgAN-AS patients differed from SIgAN-RA patients in certain clinic-pathological characteristics. HLA-B27 likely protected SIgAN-AS patients from renal insufficiency.</p>