10.6084/m9.figshare.1116302.v3
Anqiang Zhang
Anqiang
Zhang
Wenwen Deng
Wenwen
Deng
Yaling Lin
Yaling
Lin
Junhui Ye
Junhui
Ye
Yaomin Dong
Yaomin
Dong
Yufeng Lei
Yufeng
Lei
Hongtao Chen
Hongtao
Chen
Novel supramolecular elastomer films based on linear carboxyl-terminated polydimethylsiloxane oligomers: preparation, characterization, biocompatibility, and application in wound dressings
Taylor & Francis Group
2014
supramolecular
elastomer
films
linear
carboxyl-terminated
polydimethylsiloxane
dressings
2014-08-19 08:41:16
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Novel_supramolecular_elastomer_films_based_on_linear_carboxyl_terminated_polydimethylsiloxane_oligomers_preparation_characterization_biocompatibility_and_application_in_wound_dressings/1116302
<div><p>A novel supramolecular elastomer (SESi) based on multiple hydrogen bond associations between low-molecular-weight polydimethylsiloxane chains was obtained through a two-step reaction of linear carboxyl-terminated polydimethylsiloxane oligomers with diethylenetriamine and urea, and the reaction mechanism was characterized. The results of differential scanning calorimetry and X-ray diffraction analyses indicated that the supramolecular network structure is completely amorphous, endowing SESi with rubber-like elastic behavior at room temperature. The transparent SESi film prepared by hot pressing displayed nice viscoelasticity, benign water absorption, water vapor transition rates, and ideal biocompatibility; and did not show cytotoxicity or skin irritation. These properties allow the elastomer to function as an occlusive wound dressing. To demonstrate its potential in wound dressings, a detailed comparison of commercial 3M Tegaderm<sup>™</sup> film and the SESi film was conducted. The SESi film exhibited similar effects in wound healing, and the wound bed was covered by the SESi film without the occurrence of significant adverse reactions.</p></div>