10.6084/m9.figshare.11298596.v1 Daowan Lai Daowan Lai Jing Li Jing Li Siji Zhao Siji Zhao Gan Gu Gan Gu Xiao Gong Xiao Gong Peter Proksch Peter Proksch Ligang Zhou Ligang Zhou Chromone and isocoumarin derivatives from the endophytic fungus <i>Xylomelasma</i> sp. Samif07, and their antibacterial and antioxidant activities Taylor & Francis Group 2019 Endophytic fungus Xylomelasma sp. Samif07 chromone isocoumarin antibacterial activity antioxidant activity 2019-11-29 14:36:55 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Chromone_and_isocoumarin_derivatives_from_the_endophytic_fungus_i_Xylomelasma_i_sp_Samif07_and_their_antibacterial_and_antioxidant_activities/11298596 <p>Five chromone derivatives, including 2,6-dimethyl-5-methoxyl-7-hydroxylchromone (<b>1</b>), 6-hydroxymethyleugenin (<b>2</b>), 6-methoxymethyleugenin (<b>3</b>), chaetoquadrin D (<b>4</b>), and isoeugenitol (<b>5</b>), and three isocoumarin congeners, namely diaporthin (<b>6</b>), 8-hydroxy-6-methoxy-3-methylisocoumarin (<b>7</b>), and 6-methoxymellein (<b>8</b>), were isolated from the culture of the endophytic fungus <i>Xylomelasma</i> sp. Samif07 derived from the medicinal plant <i>Salvia miltiorrhiza</i> Bunge. Among them, compound <b>1</b> was a new natural product. Their structures were determined by spectroscopic methods and comparison with the literature. The isolated compounds were evaluated for their antibacterial and antioxidant activities. Compound <b>5</b> showed notable antitubercular activity against <i>Mycobacterium tuberculosis</i> with MIC value of 10.31 µg/mL, while compounds <b>1</b>–<b>3</b>, and <b>5</b>–<b>7</b> displayed inhibitory activities against the other bacteria with MIC range of 25 ∼ 100 µg/mL. Meanwhile, compound <b>6</b> showed potent hydroxyl radical-scavenging activity with EC<sub>50</sub> value of 15.1 µg/mL, while compounds <b>5</b>–<b>7</b> showed certain ferric reducing ability.</p> <p></p>