10.6084/m9.figshare.11298596.v1
Daowan Lai
Daowan
Lai
Jing Li
Jing
Li
Siji Zhao
Siji
Zhao
Gan Gu
Gan
Gu
Xiao Gong
Xiao
Gong
Peter Proksch
Peter
Proksch
Ligang Zhou
Ligang
Zhou
Chromone and isocoumarin derivatives from the endophytic fungus <i>Xylomelasma</i> sp. Samif07, and their antibacterial and antioxidant activities
Taylor & Francis Group
2019
Endophytic fungus
Xylomelasma sp. Samif07
chromone
isocoumarin
antibacterial activity
antioxidant activity
2019-11-29 14:36:55
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Chromone_and_isocoumarin_derivatives_from_the_endophytic_fungus_i_Xylomelasma_i_sp_Samif07_and_their_antibacterial_and_antioxidant_activities/11298596
<p>Five chromone derivatives, including 2,6-dimethyl-5-methoxyl-7-hydroxylchromone (<b>1</b>), 6-hydroxymethyleugenin (<b>2</b>), 6-methoxymethyleugenin (<b>3</b>), chaetoquadrin D (<b>4</b>), and isoeugenitol (<b>5</b>), and three isocoumarin congeners, namely diaporthin (<b>6</b>), 8-hydroxy-6-methoxy-3-methylisocoumarin (<b>7</b>), and 6-methoxymellein (<b>8</b>), were isolated from the culture of the endophytic fungus <i>Xylomelasma</i> sp. Samif07 derived from the medicinal plant <i>Salvia miltiorrhiza</i> Bunge. Among them, compound <b>1</b> was a new natural product. Their structures were determined by spectroscopic methods and comparison with the literature. The isolated compounds were evaluated for their antibacterial and antioxidant activities. Compound <b>5</b> showed notable antitubercular activity against <i>Mycobacterium tuberculosis</i> with MIC value of 10.31 µg/mL, while compounds <b>1</b>–<b>3</b>, and <b>5</b>–<b>7</b> displayed inhibitory activities against the other bacteria with MIC range of 25 ∼ 100 µg/mL. Meanwhile, compound <b>6</b> showed potent hydroxyl radical-scavenging activity with EC<sub>50</sub> value of 15.1 µg/mL, while compounds <b>5</b>–<b>7</b> showed certain ferric reducing ability.</p> <p></p>