%0 Journal Article %A Malinowski, Zbigniew %A K. Szcześniak, Aleksandra %A Pakulska, Wanda %A Sroczyński, Dariusz %A Czarnecka, Elżbieta %A Epsztajn, Jan %D 2014 %T Synthesis of N-(2-(Methylamino)ethyl) Derivatives of 2H-Phthalazin-1-ones %U https://tandf.figshare.com/articles/journal_contribution/Synthesis_of_i_N_i_2_Methylamino_ethyl_Derivatives_of_2_i_H_i_Phthalazin_1_ones/1132638 %R 10.6084/m9.figshare.1132638.v4 %2 https://tandf.figshare.com/ndownloader/files/1627939 %K presence %K series %K methylamino %K derivative %K Selected compounds %K MeONa %K aminoethyl %K tosyl %K Synthesi %K acetyl %K lactam %K alkyl %K yield %K Mitsunobu reaction conditions %X

A series of new alkyl, tosyl, acetyl, and tert-butoxycarbonyl derivatives of 2-(2-aminoethyl)-phthalazinones were efficiently synthesized by reaction of lactams with N-Boc-, N-acetyl-, or N,O-ditosyl derivatives of N-methylethanolamine in the presence of MeONa or under Mitsunobu reaction conditions. Selected compounds were converted into corresponding 2-[2-(methylamino)ethyl]phthalazinones in good yields.

%I Taylor & Francis