10.6084/m9.figshare.11695230.v1
Dattatraya G. Raut
Dattatraya G.
Raut
Anjana S. Lawand
Anjana S.
Lawand
Vikas D. Kadu
Vikas D.
Kadu
Mahesh G. Hublikar
Mahesh G.
Hublikar
Sandeep B. Patil
Sandeep B.
Patil
Dnyandev G. Bhosale
Dnyandev G.
Bhosale
Raghunath B. Bhosale
Raghunath B.
Bhosale
Synthesis of Asymmetric Thiazolyl Pyrazolines as a Potential Antioxidant and Anti-Inflammatory Agents
Taylor & Francis Group
2020
Anti-inflammatory activity
antioxidant activity
asymmetric 1-thiazolyl-2-pyrazolines
polycyclic aromatic compounds
2020-01-23 10:46:59
Online resource
https://tandf.figshare.com/articles/online_resource/Synthesis_of_Asymmetric_Thiazolyl_Pyrazolines_as_a_Potential_Antioxidant_and_Anti-Inflammatory_Agents/11695230
<p>A new series of 1-Thiazolyl-2-Pyrazolines <b>5a-g</b> was accomplished by reacting pyrazolealdehyde with an appropriate aromatic ketone in the presence of PEG-300 as a solvent to yield chalcone. The chalcones reacted with thiosemicarbazide to yield asymmetric 1-thiocarbamoyl pyrazoles. The above formed 1-thiocarbamoyl pyrazoles reacted with appropriate α- haloketones to yield 1-Thiazolyl-2-Pyrazolines. The structural interpretations of newly formed compounds were done by <sup>1</sup>H NMR, <a href="#CIT0013" target="_blank"><sup>13</sup></a>CNMR, IR and mass spectroscopic methods. The newly prepared asymmetric 1-Thiazolyl-2-pyrazoline derivatives were evaluated to their <i>in vitro</i> antioxidant (H<sub>2</sub>O<sub>2</sub>, DPPH, SOR and NO radical inhibiting activity) as well as anti-inflammatory activity. The 1-Thiazolyl-2-pyrazoline derivatives <b>5a-g</b> exhibited moderate to good H<sub>2</sub>O<sub>2</sub> scavenging activity as match up to ascorbic acid. All the 1-Thiazolyl-2-pyrazoline derivatives exhibited excellent SOR scavenging activity except <b>5 b</b>. All the tested compounds have shown good to excellent, NO radical inhibiting activity. DPPH radical scavenging activity results have shown low antioxidant activity. Also, all the 1-Thiazolyl-2-pyrazoline derivatives were tested for their <i>in vitro</i> anti-inflammatory activity. The compounds <b>5a</b>, <b>5 b</b>, <b>5c, 5f</b> and <b>5 g</b> were exhibited good anti-inflammatory activity and <b>5d</b> showed moderate activity while <b>5e</b> less active as match up to diclofenac sodium as a standard reference.</p>