Improved Protocol for Mononitration of Phenols with Bismuth(III) and Iron(III) Nitrates
Małgorzata Wąsińska
Anna Korczewska
Mirosław Giurg
Jacek Skarżewski
10.6084/m9.figshare.1181981.v3
https://tandf.figshare.com/articles/journal_contribution/Improved_Protocol_for_Mononitration_of_Phenols_with_Bismuth_III_and_Iron_III_Nitrates/1181981
<div><p></p><p>A simple and efficient multigram procedure was developed for the selective mononitration of various activated phenols. The reaction proceeded smoothly with 0.5 equivalents of Bi(NO<sub>3</sub>)<sub>3</sub> · 5H<sub>2</sub>O or Fe(NO<sub>3</sub>)<sub>3</sub> · 9H<sub>2</sub>O in acetone at ambient temperature or at reflux. The desired products were isolated in 62–93% total yield and essentially no overnitrated compounds were detected.</p>
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2014-11-26 05:48:46
ambient temperature
phenol
nitrate
bi
mononitration
fe
multigram procedure
overnitrated compounds
bismuth
acetone
0.5 equivalents
reflux