10.6084/m9.figshare.1182587.v3
Abdelbasset A. Farahat
Abdelbasset A.
Farahat
David W. Boykin
David W.
Boykin
Copper(I) 3-Methylsalicylate Mediates the Chan–Lam <i>N</i>-Arylation of Heterocycles
Taylor & Francis Group
2014
reaction conditions
K 2CO methanol
utility
heterocycle
mediate
CuMeSal
methylsalicylate
catalyst
aryl boronic acids
chan
yield
2014-12-08 20:01:56
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Copper_I_3_Methylsalicylate_Mediates_the_Chan_Lam_i_N_i_Arylation_of_Heterocycles/1182587
<div><p></p><p>Copper(I) 3-methylsalicylate (CuMeSal) mediates <i>N</i>-arylation reactions between aryl boronic acids and aromatic heterocycles (Chan–Lam coupling) under moderate reaction conditions (K<sub>2</sub>CO<sub>3</sub>, methanol, 65 °C, in air, 3–5 h). Both electron-rich and electron-deficient aryl boronic acids and a diverse set of <i>N</i>-heterocycles were allowed to react and gave <i>N</i>-arylation products in reasonable yields, which demonstrate the utility of this catalyst.</p>
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