Rhodium-catalysed chemo- and regio-selective [3 + 2+2] cycloadditions of bis(methylenecyclopropanes) and alkynes: Synthesis of spirocyclic 5–7 condensed cycloheptenes
Bilash Kuila
Priyanka Sharma
Dinesh Mahajan
Prabhpreet Singh
Gaurav Bhargava
10.6084/m9.figshare.11826819.v1
https://tandf.figshare.com/articles/journal_contribution/Rhodium-catalysed_chemo-_and_regio-selective_3_2_2_cycloadditions_of_bis_methylenecyclopropanes_and_alkynes_Synthesis_of_spirocyclic_5_7_condensed_cycloheptenes/11826819
<p>Rhodium-catalyzed intermolecular [3 + 2+2] cycloaddition reactions of bis(methylenecyclopropanes) with different alkynes are described. The rhodium-catalyzed [3 + 2+2] cycloadditions resulted in the formation of functionalized 5–7–3 spirocyclic carbocycles in moderate yields with excellent regio- and chemo-selectivity.</p>
2020-02-08 10:39:12
[3 + 2+2] Cycloadditions
[Rh(COD)Cl]2
bis(methylenecyclopropanes)
multicomponent reaction
spirocyclic cycloheptenes