Two new phenolic glycosides with anti-complementary activity from the roots of <i>Sanguisorba officinalis</i> L Rongshen Wang Jinfeng Sun Mei Jin Chao Ye Jiaming Wang Long Jin Ying Jie Ma Wei Zhou Gao Li 10.6084/m9.figshare.11830104.v1 https://tandf.figshare.com/articles/journal_contribution/Two_new_phenolic_glycosides_with_anti-complementary_activity_from_the_roots_of_i_Sanguisorba_officinalis_i_L/11830104 <p><i>Sanguisorba officinalis</i> L. is a traditional herbal plant that belongs to the genus <i>Sanguisorba</i> and the family Rosaceae. Two new phenolic glycosides (<b>1–2</b>), ten known phenolics (<b>3–12</b>), and six known monoterpenoid glycosides (<b>13–18</b>) were isolated from the roots of <i>S. officinalis</i> using silica gel column and preparative middle pressure liquid chromatography (MPLC). The chemical structures were elucidated based on extensive spectroscopic experiments, including 1D and 2D NMR as well as HR-ESI-MS, and comparison with those reported in the literature. Compounds <b>3–5</b>, and <b>13</b> were isolated from the Rosaceae family and compound <b>7</b> was obtained from the genus <i>Sanguisorba</i> for the first time. Additionally, all compounds were evaluated for their anti-complementary activities against the classical pathway. Furthermore, compounds <b>1</b>, <b>5</b>, <b>9</b>, and <b>14</b> showed significant anti-complementary activities with the 50% haemolytic inhibition concentrations (CH<sub>50</sub>) values of 0.40 ± 0.03, 0.57 ± 0.01, 0.51 ± 0.07, and 0.53 ± 0.05 mM, respectively.</p> <p></p> 2020-02-10 10:31:12 Sanguisorba officinalis L. Rosaceae phenolic glycoside monoterpenoid glycoside anti-complementary activity