%0 Journal Article %A Cui, Wei-Ye %A Jin, Yulian %A Liu, Hui %A Zu, Ma-Li %A Zhai, Xin-Fang %A Yang, Ce %A Gu, Yu-Long %A Cheng, Yong %A Piao, Xiang-Lan %D 2020 %T Dammarane-type saponins from Gynostemma pentaphyllum and their cytotoxicities %U https://tandf.figshare.com/articles/journal_contribution/Dammarane-type_saponins_from_i_Gynostemma_pentaphyllum_i_and_their_cytotoxicities/11830146 %R 10.6084/m9.figshare.11830146.v1 %2 https://tandf.figshare.com/ndownloader/files/21653508 %K Gynostemma pentaphyllum %K saponin %K damulin E %K damulin F %K cytotoxicity %X

Heat-processed Gynostemma pentaphyllum has shown strong activity against human lung carcinoma A549 cells. In this study, two dammarane-type saponins together with two known compounds were isolated from the ethanol extract of the heat-processed leaves of G. pentaphyllum. They were identified as 2α,3β,12β-trihydroxydammar-20(22),24-diene-3-O-β-D-glucopyranoside (1, namely damulin E), 2α,3β,12β-trihydroxydammar-20,24-diene-3-O-β-D-glucopyranoside (2, namely damulin F), damulin A (3) and damulin B (4), respectively, using NMR and mass spectra. Damulin E and damulin F showed moderate activity against A549, H1299, T24, SH-SY5Y and K562 cell lines in vitro using CCK-8 assay.

%I Taylor & Francis