Decarboxylation of indole-3-carboxylic acids under metal-free conditions
Xia Chen
Xiao-Yu Zhou
10.6084/m9.figshare.11854908.v1
https://tandf.figshare.com/articles/journal_contribution/Decarboxylation_of_indole-3-carboxylic_acids_under_metal-free_conditions/11854908
<p>Two reaction systems have been developed for the decarboxylation of indole-3-carboxylic acids. The decarboxylation can be achieved smoothly under K<sub>2</sub>CO<sub>3</sub>-catalyzed or acetonitrile-promoted basic conditions. It provided an efficient and simple method for the transformation of indole-3-carboxylic acids and the corresponding indoles were isolated with good to excellent yields. From the experimental facts, we put forward the possible reaction mechanism.</p>
2020-02-14 12:50:02
Decarboxylation
indole-3-carboxylic acids
indoles
metal-free