10.6084/m9.figshare.1308464.v4
Lei Zhang
Lei
Zhang
Hai-Qing Lin
Hai-Qing
Lin
Gui-Sheng Li
Gui-Sheng
Li
Xi-Dian Yue
Xi-Dian
Yue
Sheng-Jun Dai
Sheng-Jun
Dai
New sesquiterpenoid derivatives from <i>Solanum septemlobum</i> with cytotoxicities
Taylor & Francis Group
2015
cancer cell lines
roesy
ht
sesquiterpenoid derivatives
cosy
hmbc
Solanum septemlobum
IC 50 values
HONE
hmqc
New sesquiterpenoid derivatives
2015-10-08 11:39:15
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/New_sesquiterpenoid_derivatives_from_i_Solanum_septemlobum_i_with_cytotoxicities/1308464
<div><p>Two new sesquiterpenoid derivatives, attributable to eudesmane-type (<b>1</b>–<b>2</b>, named septemlobin D and 11,12-<i>O</i>-isopropylidenesolajiangxin F), were isolated from the whole plant of <i>Solanum septemlobum</i>. Their structures were elucidated on the basis of integrated spectroscopic techniques, mainly HR-FAB-MS, 1D and 2D-NMR (<sup>1</sup>H–<sup>1</sup>H COSY, HMQC, HMBC and ROESY). <i>In vitro</i>, two sesquiterpenoid derivatives were found to show significant cytotoxicity against three cancer cell lines (P-388, HONE-1 and HT-29), and gave IC<sub>50</sub> values in the range of 3.0–7.3 μM.</p></div>