Biological activities of <i>Peristrophe bivalvis</i> extracts: promising potential for anti-snake venoms against <i>Naja kaouthia</i> and <i>Trimeresurus</i> <i>albolabris</i> venoms
Jatuporn Phaopongthai
Jureeporn Noiphrom
Supat Phaopongthai
Narumol Pakmanee
Jirapast Sichaem
10.6084/m9.figshare.1403696.v1
https://tandf.figshare.com/articles/journal_contribution/Biological_activities_of_i_Peristrophe_bivalvis_i_extracts_promising_potential_for_anti_snake_venoms_against_i_Naja_kaouthia_i_and_i_Trimeresurus_i_i_albolabris_i_venoms/1403696
<div><p>This study evaluates the <i>in vitro</i> anti-snake venom potential of <i>Peristrophe bivalvis</i> (PB) extracts against <i>Naja kaouthia</i> (NK) and <i>Trimeresurus</i> <i>albolabris</i> (TA) venoms, including inhibition of cytotoxic effects and enzymatic activities, and the binding-precipitation of extracts and venom proteins analysis. In addition, the antioxidant, cytotoxic and <i>in vivo</i> acute oral toxic activities of PB extracts are also reported. The <i>in vitro</i> cytotoxic and enzymatic analysis reveals that the ethanol extracts of stems and leaves of PB showed good anti-snake venom activity against NK and TA venoms. In addition, the antioxidant result indicated that only the ethanol extract of leaves exhibited weak DPPH radical-scavenging activity. The ethanol whole-plant extract of PB also showed no cytotoxicity against four cell lines. Moreover, the <i>in vivo</i> acute oral toxicity result of the ethanol whole-plant extract showed that all treated rats did not exhibit abnormal toxic signs or deaths.</p></div>
2015-05-05 00:00:00
nk
pb
ta
dpph
ethanol
cytotoxic
venom proteins analysis
Peristrophe bivalvis extracts
Naja kaouthia