10.6084/m9.figshare.1416162.v3
Satish Kumar Vujjini
Satish
Kumar Vujjini
Sunitha Vyala
Sunitha
Vyala
Krishna Rao Badarla
Krishna
Rao Badarla
Sreenatha Charyulu Kandala
Sreenatha
Charyulu Kandala
Rakeshwar Bandichhor
Rakeshwar
Bandichhor
Mukkanti Kagga
Mukkanti
Kagga
Praveen Cherukupalli
Praveen
Cherukupalli
Simple and Efficient Process for the Large-Scale Preparation of Agomelatine: An Antidepressant Drug
Taylor & Francis Group
2015
sodium diformylamide
Key steps
Efficient Process
nucleophilic displacement
Antidepressant Drug
scalable process
chloroacetyl chloride
agomelatine
2015-07-20 18:00:46
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Simple_and_Efficient_Process_for_the_Large_Scale_Preparation_of_Agomelatine_An_Antidepressant_Drug/1416162
<div><p></p><p>A simple and efficient process for the large-scale preparation of agomelatine (<b>1</b>), an antidepressant drug is, described. Agomelatine was prepared in a linear manner starting from readily available, inexpensive 2-naphthol. Key steps in the synthesis are Friedel–Crafts acylation of 2-naphthyl acetate with chloroacetyl chloride, reduction of keto intermediate, and nucleophilic displacement of chloro intermediate with sodium diformylamide. A systemic approach was described to streamline the process into a robust scalable process by controlling the impurities.</p></div>