10.6084/m9.figshare.1568950.v1
Ana Martín-Cameán
Ana
Martín-Cameán
Angeles Jos
Angeles
Jos
Ana M. Cameán
Ana
M. Cameán
Enrique Solano
Enrique
Solano
Alejandro Iglesias-Linares
Alejandro
Iglesias-Linares
Genotoxic and cytotoxic effects and gene expression changes induced by fixed orthodontic appliances in oral mucosa cells of patients: a systematic review
Taylor & Francis Group
2015
gene expression changes
prisma
genotoxic
Preferred Reporting Items
DNA
rct
mucosa cells
2015-07-24 00:00:00
Dataset
https://tandf.figshare.com/articles/dataset/Genotoxic_and_cytotoxic_effects_and_gene_expression_changes_induced_by_fixed_orthodontic_appliances_in_oral_mucosa_cells_of_patients_a_systematic_review/1568950
<div><p></p><p><i>Context</i>: The accumulation of chronic or severe acute DNA and cellular damage in oral mucosa cells is one of the main factors that help initiate a wide range of malignant lesions in the oral cavity. There has been considerable controversy in the literature about the effect of such sustained genotoxic and cytotoxic damage to oral mucosa cells.</p><p><i>Objective</i>: The aim of this systematic review, reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, is to investigate the effects of such interventions.</p><p><i>Methods</i>: Electronic and manual searches were performed (15 May 2015) for Randomized Clinical Trials/quasi-Randomized Clinical Trials that analyzed the genotoxic/cytotoxic effects of these types of oral appliances in humans. A primary outcome (cell/DNA damage) and a number of secondary outcomes were examined. Two reviewers carried out the study selection and performed a “risk of bias” assessment [Cochrane Collaboration's tool]. Wherever possible the meta-analysis was conducted on homogenous groups.</p><p><i>Results</i>: From the electronic search (2797), 6 studies met the eligibility criteria. Most studies (5/6) observed significant differences in most comparisons at the short-term (1-3 months) and long-term (24–48 months) evaluations, with respect to critically acute genotoxic/cytotoxic effects. Some of the studies (2/3) concluded that the post-removable effects at DNA/cellular levels were not significant (<i>p</i> > 0.05) with respect to the controls.</p><p><i>Conclusions</i>: Acute DNA/cellular damage in oral mucosa cells is induced by orthodontic appliances. Nevertheless, even though these effects were no longer detected after removing the appliances, more rigorous RCTs are needed to explore the extent to which acquired damage can be observed in the oral mucosa.</p></div>