10.6084/m9.figshare.1569211.v6 Xinying Zhang Xinying Zhang Lin Gao Lin Gao Zhangxin Wang Zhangxin Wang Xuesen Fan Xuesen Fan Water-Mediated Selective Synthesis of Pyrazolo[1,5-<i>a</i>]quinazolin-5(4<i>H</i>)-ones and [1,2,4]Triazolo[1,5-<i>a</i>]quinazolin-5(4<i>H</i>)-one via Copper-Catalyzed Cascade Reactions Taylor & Francis Group 2015 bromobenzoate triazolo literature protocols chemoselective formation reaction medium Pyrazolo synthesis material cascade method title compounds copper catalyst Synthesi procedure 2015-10-28 01:12:18 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Water_Mediated_Selective_Synthesis_of_Pyrazolo_1_5_i_a_i_quinazolin_5_4_i_H_i_ones_and_1_2_4_Triazolo_1_5_i_a_i_quinazolin_5_4_i_H_i_one_via_Copper_Catalyzed_Cascade_Reactions/1569211 <div><p></p><p>A convenient and sustainable synthesis of pyrazolo[1,5-<i>a</i>]quinazolin-5(4<i>H</i>)-ones and [1,2,4]triazolo[1,5-<i>a</i>]quinazolin-5(4<i>H</i>)-one through copper-catalyzed cascade reactions of 2-bromobenzoates with 1<i>H</i>-pyrazol-5-amines or 1<i>H</i>-1,2,4-triazol-5-amine under ligand-free conditions in water is presented. It is notable that aqueous medium turned out to be crucial for the chemoselective formation of the title compounds. Compared with literature protocols, this new method showed advantages such as simple and sustainable procedure, commercially available starting materials, and convenient reuse of the reaction medium together with the copper catalyst.</p></div>