10.6084/m9.figshare.1613403.v1 Guo-Fang Jiang Guo-Fang Jiang Zong-Bo Xie Zong-Bo Xie Shi-Guo Zhang Shi-Guo Zhang Da-Zhao Sun Da-Zhao Sun Zhang-Gao Le Zhang-Gao Le The green synthesis of 2,3-dihydroquinazolin-4(1<i>H</i>)-ones via direct cyclocondensation reaction under catalyst-free conditions Taylor & Francis Group 2015 reaction conditions reaction time substrate molar ratio synthesis ABSTRACTA dihydroquinazolin reaction medium workup process cyclocondensation reaction 2015-10-02 00:00:00 Journal contribution https://tandf.figshare.com/articles/journal_contribution/The_green_synthesis_of_2_3_dihydroquinazolin_4_1_i_H_i_ones_via_direct_cyclocondensation_reaction_under_catalyst_free_conditions/1613403 <div><p>ABSTRACT</p><p>A simple and environmentally benign method is described for the synthesis of 2,3-dihydroquinazolin-4(1<i>H</i>)-ones by direct cyclocondensation of 2-aminobenzamide with aromatic aldehydes using water as the reaction medium. The parameters such as temperature, substrate molar ratio and reaction time were examined to establish the optimal synthetic process. The present procedure has advantages of low cost, mild reaction conditions, simple workup process, simply purification, excellent yields and no use of catalyst and hazardous organic solvents.</p></div>