%0 Generic %A Enroth, Stefan %A Johansson, Åsa %A Gyllensten, Ulf %A Bosdotter Enroth, Sofia %D 2015 %T Effect of genetic and environmental factors on protein biomarkers for common non-communicable disease and use of personally normalized plasma protein profiles (PNPPP) %U https://tandf.figshare.com/articles/dataset/Effect_of_genetic_and_environmental_factors_on_protein_biomarkers_for_common_non_communicable_disease_and_use_of_personally_normalized_plasma_protein_profiles_PNPPP_/1613543 %R 10.6084/m9.figshare.1613543.v1 %2 https://tandf.figshare.com/ndownloader/files/2593551 %2 https://tandf.figshare.com/ndownloader/files/2593552 %2 https://tandf.figshare.com/ndownloader/files/2593553 %2 https://tandf.figshare.com/ndownloader/files/2593554 %2 https://tandf.figshare.com/ndownloader/files/2593555 %K lifestyle factors %K plasma protein profiles %K protein biomarkers %K Proximity extension assays %K PNPPP %K measure 145 proteins %X

Objective: To study the impact of genetic and lifestyle factors on protein biomarkers and develop personally normalized plasma protein profiles (PNPPP) controlling for non-disease-related variance.

Materials and methods: Proximity extension assays were used to measure 145 proteins in 632 controls and 344 cases with non-communicable diseases.

Results: Genetic and lifestyle factors explained 20–88% of the variation in healthy controls. Adjusting for these factors reduced the number of candidate biomarkers by 63%.

Conclusion: PNPPP efficiently controls for non-disease-related variance, allowing both for efficient discovery of novel biomarkers and for covariate-independent linear cut-offs suitable for clinical use.

%I Taylor & Francis