10.6084/m9.figshare.1625340.v1
Steven Joniau
Steven
Joniau
Karin Haustermans
Karin
Haustermans
Christophe M. Deroose
Christophe M.
Deroose
Sofie Isebaert
Sofie
Isebaert
Raymond Oyen
Raymond
Oyen
Felix M. Mottaghy
Felix
M. Mottaghy
Hendrik van Poppel
Hendrik
van Poppel
Evelyne Lerut
Evelyne
Lerut
Laura Van den Bergh
Laura
Van den Bergh
Filip Ameye
Filip
Ameye
Joost Berkers
Joost
Berkers
Reliability of sentinel node procedure for lymph node staging in prostate cancer patients at high risk for lymph node involvement
Taylor & Francis Group
2015
lymph node
sn
lymph node involvement
iqr
prostate cancer patients
spect
superextended LN dissection
gamma probe
LN involvement
seLND
sentinel node procedure
2015-12-17 08:11:31
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Reliability_of_sentinel_node_procedure_for_lymph_node_staging_in_prostate_cancer_patients_at_high_risk_for_lymph_node_involvement/1625340
<div><p></p><p><b>Aim.</b> To investigate the reliability of a sentinel node (SN) procedure for nodal staging in prostate cancer (PCa) patients at high risk for lymph node (LN) involvement.</p><p><b>Material and methods.</b> Seventy-four patients with localized prostate adenocarcinoma, who were clinically node-negative and had a risk of LN involvement of ≥ 10% (Partin tables), were prospectively enrolled. Upon intraprostatic 99mTc-nanocolloid injection, they underwent planar scintigraphy and SPECT imaging. Surgical removal of the SN, located by means of a gamma probe, was completed with a superextended LN dissection (seLND) as a reference and followed by radical prostatectomy.</p><p><b>Results.</b> In total, 470 SN (median 6, IQR 3–9) were scintigraphically detected of which 371 (median 4, IQR 2–6) were located by gamma probe and selectively removed during surgery (79%). Histopathology confirmed LN metastases in 37 patients (50%) having 106 affected LN in total (median number per patient 2, IQR 1–4). Twenty-eight patients were node positive (N+) based on the analysis of the resected SN. However, the seLND that was performed as a reference revealed nine additional N+ patients resulting in a sensitivity of 76% (28/37). In total, 15 of 37 patients (41%) had metastases in SN only and could have been spared seLND to remove all affected nodes.</p><p><b>Conclusion.</b> We found a relatively low sensitivity when addressing the SN procedure for nodal staging in PCa patients at high risk for LN involvement. Importantly, only less than half of the N+ patients could have been spared a seLND to remove all affected lymphoid tissue.</p></div>