10.6084/m9.figshare.1629346 Sarah-Jo Stimpson Sarah-Jo Stimpson Erin C. Rebele Erin C. Rebele Michael R. DeBaun Michael R. DeBaun Common gynecological challenges in adolescents with sickle cell disease Taylor & Francis Group 2016 Contraception menstrual cycle progesterone sickle cell anemia sickle cell disease vaso-occlusive pain menorrhagia iron deficiency anemia 2016-01-05 14:53:06 Dataset https://tandf.figshare.com/articles/dataset/Common_gynecological_challenges_in_adolescents_with_sickle_cell_disease/1629346 <p>Sickle cell anemia is one of the most common genetic blood disorders worldwide. Individuals with sickle cell disease (SCD) experience clinical manifestations such as chronic anemia, developmental delay, vaso-occlusive pain, acute chest syndrome, and neurological complications. Adolescent girls with SCD face unique gynecological challenges including delayed puberty marked by a later onset in menarche, vaso-occlusive pain associated with their menstrual cycle, and underdiagnosed abnormal uterine bleeding. This review focuses on these challenges with particular emphasis on delayed menarche and vaso-occlusive pain episodes associated with menstruation, in addition to the evaluation and initial management of heavy menstrual bleeding for adolescents with SCD. We highlight research opportunities in this neglected area to help enhance the comprehensive care model for this population.</p>