10.6084/m9.figshare.2064495
Xiuqing Han
Xiuqing
Han
Chunhua Liu
Chunhua
Liu
Yong Xue
Yong
Xue
Jingfeng Wang
Jingfeng
Wang
Changhu Xue
Changhu
Xue
Teruyoshi Yanagita
Teruyoshi
Yanagita
Xiang Gao
Xiang
Gao
Yuming Wang
Yuming
Wang
Long-term fatty liver-induced insulin resistance in orotic acid-induced nonalcoholic fatty liver rats
Taylor & Francis Group
2016
glucose intolerance
insulin signaling
lipids
fatty liver
2016-01-18 13:29:07
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Long_term_fatty_liver_induced_insulin_resistance_in_orotic_acid_induced_nonalcoholic_fatty_liver_rats/2064495
<p>We investigated whether fatty liver preceded insulin resistance or vice versa using a long-term orotic acid (OA)-induced nonalcoholic fatty liver disease (NAFLD) model without the confounding effects of obesity and hyperlipidemia and explored the role of the liver in insulin resistance. Male Wistar rats were fed with or without OA supplementation for 30, 60, and 90 days. The NAFLD group showed increased liver lipid at 30, 60, and 90 days; glucose intolerance was noted at 60 and 90 days. Furthermore, partial liver proteins and gene expressions related to upstream signaling of insulin were decreased. However, the liver glycogen content was elevated, and gluconeogenesis genes expressions were obviously decreased at 90 days. The occurrence of fatty liver preceded insulin resistance in OA-induced NAFLD without the interference of obesity and hyperlipidemia, and hepatic insulin resistance may not play a conclusive role in insulin resistance in this model.</p> <p>Whether fatty liver preceded insulin resistance (IR) or vice versa in a long-term orotic acid-induced NAFLD model without the confounding effects of obesity and hyperlipidemia.</p>