10.6084/m9.figshare.2066700.v1
Zhiyong Guo
Zhiyong
Guo
Xueshuang Li
Xueshuang
Li
Liang Zhang
Liang
Zhang
Ziwei Feng
Ziwei
Feng
Zhangshuang Deng
Zhangshuang
Deng
Haibo He
Haibo
He
Kun Zou
Kun
Zou
Cytotoxic tremulanes and 5,6-secotremulanes, four new sesquiterpenoids from a plant-associated fungus X1-2
Taylor & Francis Group
2016
Tremulanes
5,6-secotremulanes
plant-associated fungus
secondary metabolites
cytotoxic activity
2016-01-22 09:41:57
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Cytotoxic_tremulanes_and_5_6_secotremulanes_four_new_sesquiterpenoids_from_a_plant_associated_fungus_X1_2/2066700
<p>Two new tremulanes and two new 5,6-secotremulanes, davotremulanes A-D <b>1</b>–<b>4</b>, along with four known compounds <b>5</b>–<b>8</b>, were isolated from the culture extract of X1-2, an unidentified plant-associated fungus, which was isolated from the endangered plant, <i>Davidia involucrate</i> Baill. in Shennongjia District. The structures of new compounds <b>1</b>–<b>4</b> were established on the basis of extensive spectroscopic analysis. Compounds <b>1</b>–<b>8</b> were evaluated for cytotoxic activity to four cancer cell lines, and compounds <b>1</b>, <b>2</b> and <b>5</b> displayed selectively moderate activities to A549 cell line with IC<sub>50</sub> at 15.3, 25.2, 35.2 μg/mL.</p>