10.6084/m9.figshare.2066700.v1 Zhiyong Guo Zhiyong Guo Xueshuang Li Xueshuang Li Liang Zhang Liang Zhang Ziwei Feng Ziwei Feng Zhangshuang Deng Zhangshuang Deng Haibo He Haibo He Kun Zou Kun Zou Cytotoxic tremulanes and 5,6-secotremulanes, four new sesquiterpenoids from a plant-associated fungus X1-2 Taylor & Francis Group 2016 Tremulanes 5,6-secotremulanes plant-associated fungus secondary metabolites cytotoxic activity 2016-01-22 09:41:57 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Cytotoxic_tremulanes_and_5_6_secotremulanes_four_new_sesquiterpenoids_from_a_plant_associated_fungus_X1_2/2066700 <p>Two new tremulanes and two new 5,6-secotremulanes, davotremulanes A-D <b>1</b>–<b>4</b>, along with four known compounds <b>5</b>–<b>8</b>, were isolated from the culture extract of X1-2, an unidentified plant-associated fungus, which was isolated from the endangered plant, <i>Davidia involucrate</i> Baill. in Shennongjia District. The structures of new compounds <b>1</b>–<b>4</b> were established on the basis of extensive spectroscopic analysis. Compounds <b>1</b>–<b>8</b> were evaluated for cytotoxic activity to four cancer cell lines, and compounds <b>1</b>, <b>2</b> and <b>5</b> displayed selectively moderate activities to A549 cell line with IC<sub>50</sub> at 15.3, 25.2, 35.2 μg/mL.</p>