%0 Journal Article %A Rafiq, Zumaana %A Narasimhan, Sreevidya %A Vennila, Rosy %A Vaidyanathan, Rama %D 2016 %T Punigratane, a novel pyrrolidine alkaloid from Punica granatum rind with putative efflux inhibition activity %U https://tandf.figshare.com/articles/journal_contribution/Punigratane_a_novel_pyrrolidine_alkaloid_from_i_Punica_granatum_i_rind_with_putative_efflux_inhibition_activity/2802610 %R 10.6084/m9.figshare.2802610.v1 %2 https://tandf.figshare.com/ndownloader/files/4497019 %K Pyrrolidine alkaloid %K Punigratane %K Punica granatum %K pomegranate rind %K RND efflux pump inhibitor %K multidrug resistance %K Klebsiella pneumoniae %X

A new pyrrolidine alkaloid named Punigratane was isolated from the rind of Punica granatum. This is the first report of a pyrrolidine-like structure from the rind. The activity of this compound was tested in a representative MDR Klebsiella pneumoniae strain which exhibited high efflux pump activity. At a concentration of 6 mg, this compound Punigratane was found to have efflux inhibition activity.

%I Taylor & Francis