10.6084/m9.figshare.2867305
Navjot Kanwar
Navjot
Kanwar
Rakesh Kumar
Rakesh
Kumar
Amita Sarwal
Amita
Sarwal
V. R. Sinha
V.
R. Sinha
Preparation and evaluation of floating tablets of pregabalin
Taylor & Francis Group
2016
FTIR
HPMC K 100. Optimized formulations
PTZ
pregabalin
stability studies
drug release
optimized tablet batch
DSC
vivo pharmacodynamic studies
Carbopol 974 P NF
xanthan gum
2016-02-26 10:29:35
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Preparation_and_evaluation_of_floating_tablets_of_pregabalin/2867305
<p>Floating tablets of pregabalin were prepared using different concentrations of the gums (xanthan gum and guar gum), Carbopol 974P NF and HPMC K100. Optimized formulations were studied for physical tests, floating time, swelling behavior, <i>in vitro</i> release studies and stability studies. <i>In vitro</i> drug release was higher for tablet batches containing guar and xanthan gum as compared to the batches containing Carbopol 974P NF. Tablet batches were subjected to stability studies and evaluated by different parameters (drug release, drug content, FTIR and DSC studies). The optimized tablet batch was selected for <i>in vivo</i> pharmacodynamic studies (PTZ induced seizures). The results obtained showed that the onset of jerks and clonus were delayed and extensor phase was abolished with time in treated groups. A significant difference (<i>p</i> > 0.05) was observed in control and treated group behavior indicating an excellent activity of the formulation for a longer period (>12 h).</p>