10.6084/m9.figshare.3084127.v1
Danielle Cardoso de Alencar
Danielle
Cardoso de Alencar
Maria Lúcia Belém Pinheiro
Maria
Lúcia Belém Pinheiro
José Lamak da Silva Pereira
José
Lamak da Silva Pereira
João Ernesto de Carvalho
João
Ernesto de Carvalho
Francinete Ramos Campos
Francinete
Ramos Campos
Alessandra Freitas Serain
Alessandra
Freitas Serain
Ricardo Brunelli Tirico
Ricardo
Brunelli Tirico
Alvaro José Hernández-Tasco
Alvaro
José Hernández-Tasco
Emmanoel Vilaça Costa
Emmanoel
Vilaça Costa
Marcos José Salvador
Marcos
José Salvador
Chemical composition of the essential oil from the leaves of <i>Anaxagorea brevipes</i> (Annonaceae) and evaluation of its bioactivity
Taylor & Francis Group
2016
Anaxagorea brevipes
Annonaceae
essential oil
bioactivity
2016-03-04 16:10:46
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Chemical_composition_of_the_essential_oil_from_the_leaves_of_i_Anaxagorea_brevipes_i_Annonaceae_and_evaluation_of_its_bioactivity/3084127
<p>The essential oil obtained by hydrodistillation from leaves of <i>Anaxagorea brevipes</i> was analysed by gas chromatography fitted with a flame ionisation detector (GC–FID) and coupled to mass spectrometry (GC–MS). Thirty one components were identified, representing around 75.7% of total oil. The major components were β-eudesmol (13.16%), α-eudesmol (13.05%), γ-eudesmol (7.54%), guaiol (5.12%), caryophyllene oxide (4.18%) and β-bisabolene (4.10%). The essential oil showed antimicrobial activity against Gram-positive bacteria and yeast with the MIC values between 25.0 and 100 μg/mL. The highest antiproliferative activity was observed for the oil against MCF-7 (breast, TGI = 12.8 μg/mL), NCI-H460 (lung, TGI = 13.0 μg/mL) and PC-3 (prostate, TGI = 9.6 μg/mL) cell lines, while against no cancer cell line HaCat (keratinocyte) the TGI was 38.8 μg/mL. The oil exhibited a small antioxidant activity assessed through ORAC-FL assay (517 μmol TE/g). This is the first report regarding the chemical composition and bioactivity of <i>A. brevipes</i> essential oil.</p>