10.6084/m9.figshare.3084127.v1 Danielle Cardoso de Alencar Danielle Cardoso de Alencar Maria Lúcia Belém Pinheiro Maria Lúcia Belém Pinheiro José Lamak da Silva Pereira José Lamak da Silva Pereira João Ernesto de Carvalho João Ernesto de Carvalho Francinete Ramos Campos Francinete Ramos Campos Alessandra Freitas Serain Alessandra Freitas Serain Ricardo Brunelli Tirico Ricardo Brunelli Tirico Alvaro José Hernández-Tasco Alvaro José Hernández-Tasco Emmanoel Vilaça Costa Emmanoel Vilaça Costa Marcos José Salvador Marcos José Salvador Chemical composition of the essential oil from the leaves of <i>Anaxagorea brevipes</i> (Annonaceae) and evaluation of its bioactivity Taylor & Francis Group 2016 Anaxagorea brevipes Annonaceae essential oil bioactivity 2016-03-04 16:10:46 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Chemical_composition_of_the_essential_oil_from_the_leaves_of_i_Anaxagorea_brevipes_i_Annonaceae_and_evaluation_of_its_bioactivity/3084127 <p>The essential oil obtained by hydrodistillation from leaves of <i>Anaxagorea brevipes</i> was analysed by gas chromatography fitted with a flame ionisation detector (GC–FID) and coupled to mass spectrometry (GC–MS). Thirty one components were identified, representing around 75.7% of total oil. The major components were β-eudesmol (13.16%), α-eudesmol (13.05%), γ-eudesmol (7.54%), guaiol (5.12%), caryophyllene oxide (4.18%) and β-bisabolene (4.10%). The essential oil showed antimicrobial activity against Gram-positive bacteria and yeast with the MIC values between 25.0 and 100 μg/mL. The highest antiproliferative activity was observed for the oil against MCF-7 (breast, TGI = 12.8 μg/mL), NCI-H460 (lung, TGI = 13.0 μg/mL) and PC-3 (prostate, TGI = 9.6 μg/mL) cell lines, while against no cancer cell line HaCat (keratinocyte) the TGI was 38.8 μg/mL. The oil exhibited a small antioxidant activity assessed through ORAC-FL assay (517 μmol TE/g). This is the first report regarding the chemical composition and bioactivity of <i>A. brevipes</i> essential oil.</p>