Kumarathasan, Premkumari Vincent, Renaud Bielecki, Agnieszka Blais, Erica Blank, Katrin Das, Dharani Karthikeyan, Subramanian Cakmak, Sabit Fisher, Mandy Arbuckle, Tye Fraser, William Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study <p><i>Background</i>: There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects.</p> <p><i>Methods and results</i>: Third trimester maternal plasma (<i>n</i> = 144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was analysed for vascular, inflammatory and oxidative stress markers by HPLC-fluorescence, protein array and EIA method. Analysis of the <25th and >75th percentile birth weight subgroups revealed markers associated with birth weight (ETs, MMP-9, VEGF, and 8-isoPGF-2α) and gestational age (ET-1, MMP-2, and VEGF).</p> <p><i>Conclusions</i>: Mechanistic insights into adverse birth outcome pathways can be achieved by integrating information on multiple biomarkers, physiology using systems biology approach.</p> MIREC study Background;Environmental Chemicals Study;MMP;birth effects;percentile birth weight subgroups;oxidative stress markers;VEGF;Mechanistic insights;birth weight;Infant birth weight;ET;plasma markers;protein array;birth outcomes;Third trimester;systems biology approach;EIA method;birth outcome pathways 2016-04-05
    https://tandf.figshare.com/articles/journal_contribution/Infant_birth_weight_and_third_trimester_maternal_plasma_markers_of_vascular_integrity_the_MIREC_study/3153802
10.6084/m9.figshare.3153802.v1