A rapid, mild, and efficient method for C-5 iodination/thiocyanation of 2-aminothiazoles HebadeMadhav J. KambleRahul D. HeseShrikant V. MoglePratima P. AmbhoreAjay N. KadamShuddhodan N. DawaneBhaskar S. 2016 <p>An efficient, green, rapid multitasking protocol for the selective C-5 substitution of 2-aminothiazole using iodic acid and aqueous PEG-400 was developed. The method found suitable for C-5 substitution i.e. iodination and thiocyanation of 2-amino thiazole using iodine and ammonium thiocyanate respectively. Iodic acid was found to be a good oxidant and aqueous PEG-400 as green reaction solvent.</p>