Vallabhajosyula, Saraschandra Sundaragiri, Pranathi R. Kanmanthareddy, Arun Ahmed, Anas A. Haddad, Toufik Mahfood Rayes, Hamza A.A. Khan, Anila N. Buaisha, Haitam M. Pershwitz, Gene E. McCann, Dustin A. Holmberg, Mark J. Morrow, Lee E. Influence of Left Ventricular Hypertrophy on In-Hospital Outcomes in Acute Exacerbation of Chronic Obstructive Pulmonary Disease <p>Left ventricular hypertrophy (LVH) is associated with worse outcomes in chronic obstructive pulmonary disease (COPD); however, its role in an acute exacerbation of COPD (AECOPD) has not been reported. This was a retrospective cohort study during 2008–2012 at an academic medical center. AECOPD patients >18 years with available echocardiographic data were included. LVH was defined as LV mass index (LVMI) >95 g/m<sup>2</sup> (women) and >115g/m<sup>2</sup> (men). Relative wall thickness was used to classify LVH as concentric (>0.42) or eccentric (<0.42). Outcomes included need for and duration of non-invasive ventilation (NIV) and mechanical ventilation (MV), NIV failure, intensive care unit (ICU) and total length of stay (LOS), and in-hospital mortality. Two-tailed p < 0.05 was considered statistically significant. Of 802 patients with AECOPD, 615 patients with 264 (42.9%) having LVH were included. The LVH cohort had higher LVMI (141.1 ± 39.4 g/m<sup>2</sup> vs. 79.7 ± 19.1 g/m<sup>2</sup>; p < 0.001) and lower LV ejection fraction (44.5±21.9% vs. 50.0±21.6%; p ≤ 0.001). The LVH cohort had statistically non-significant longer ICU LOS, and higher NIV and MV use and duration. Of the 264 LVH patients, concentric LVH (198; 75.0%) was predictive of greater NIV use [82 (41.4%) vs. 16 (24.2%), p = 0.01] and duration (1.0 ± 1.9 vs. 0.6 ± 1.4 days, p = 0.01) compared to eccentric LVH. Concentric LVH remained independently associated with NIV use and duration. In-hospital outcomes in patients with AECOPD were comparable in patients with and without LVH. Patients with concentric LVH had higher NIV need and duration in comparison to eccentric LVH.</p> Acute exacerbation of chronic obstructive pulmonary disease;left ventricular hypertrophy;left ventricular mass index;concentric hypertrophy;non-invasive ventilation 2016-07-05
    https://tandf.figshare.com/articles/journal_contribution/Influence_of_Left_Ventricular_Hypertrophy_on_In-Hospital_Outcomes_in_Acute_Exacerbation_of_Chronic_Obstructive_Pulmonary_Disease/3471548
10.6084/m9.figshare.3471548.v1