%0 Journal Article %A Suresh, Garbapu %A Nadh, Ratnakaram Venkata %A Srinivasu, Navuluri %A Kaushal, Kishore %D 2016 %T Novel coumarin isoxazoline derivatives: Synthesis and study of antibacterial activities %U https://tandf.figshare.com/articles/journal_contribution/Novel_Coumarin_Isoxazoline_Derivatives_Synthesis_and_Study_of_Antibaterial_Activities/3997437 %R 10.6084/m9.figshare.3997437 %2 https://tandf.figshare.com/ndownloader/files/6408645 %K Antibacterial activity %K coumarin isoxazoline %K [3 + 2] cycloaddition %K 1,3-dipolar cycloaddition %K hydroximoyl chloride %K nitrile oxide %X

A highly efficient and mild protocol for the syntheses of ethyl-3-[7-benzyloxy-4-methyl-2-oxo-2H-8-chromenyl]-5-aryl-4,5-dihydro-4-isoxazole carboxylates and ethyl-3-[7-benzyloxy-3-chloro-4-methyl-2-oxo-2H-8-chromenyl]-5-aryl-4,5-dihydro-4-isoxazole carboxylates in good yields via [3 + 2] cycloaddition of in situ–generated nitrile oxides from 7-benzyloxy-4-methyl-coumarin hydroxymoylchlorides and 7-benzyloxy-3-chloro-4-methyl-coumarin hydroxymoylchlorides respectively with ethyl-3-aryl prop-2-enoate has been developed. The new compounds are screened for antibacterial activity.

%I Taylor & Francis