10.6084/m9.figshare.4038915 Sivalingam Lakshmanan Sivalingam Lakshmanan Narayanan Ramalakshmi Narayanan Ramalakshmi One-pot, four-component synthesis of benzylpyrazolyl naphthoquinone derivatives and molecular docking studies Taylor & Francis Group 2016 2-Hydroxy naphthoquinone molecular docking one-pot synthesis 2016-12-05 15:48:09 Journal contribution https://tandf.figshare.com/articles/journal_contribution/One-Pot_Four-Component_Synthesis_of_Benzylpyrazolyl_Naphthoquinone_Derivatives_and_Molecular_Docking_Studies/4038915 <p>A highly efficient, green, one-pot, four-component approach for the synthesis of benzylpyrazolyl naphthoquinone derivatives (<b>5a–p</b>) have been developed by the domino reaction of 2-hydroxy naphthoquinone, aromatic aldehyde, ethyl acetoacetate, and phenyl hydrazine derivatives in water and employed p-toluene sulfonic acid (p-TSA) as the right choice of catalyst at reflux. Docking simulation was performed to position compounds <b>5a, 5b</b>, and <b>5g</b> into the anaplastic lymphoma kinase (ALK) structure active site to determine the probable binding model.</p>