10.6084/m9.figshare.4203381.v1
Mahiru Kawano
Mahiru
Kawano
Hiroko Komura
Hiroko
Komura
Haruna Kawaguchi
Haruna
Kawaguchi
Shoko Shimizu
Shoko
Shimizu
Namiko Yada-Hashimoto
Namiko
Yada-Hashimoto
Mariko Shimizu
Mariko
Shimizu
Maho Sato
Maho
Sato
Masami Inoue
Masami
Inoue
Shinobu Ida
Shinobu
Ida
Yuri Etani
Yuri
Etani
Yasuko Shoji
Yasuko
Shoji
Mariko Nakacho
Mariko
Nakacho
Kenjiro Sawada
Kenjiro
Sawada
Tadashi Kimura
Tadashi
Kimura
Nobuaki Mitsuda
Nobuaki
Mitsuda
Hirohisa Kurachi
Hirohisa
Kurachi
Ovarian insufficiency following allogeneic hematopoietic stem cell transplantation
Taylor & Francis Group
2016
Hematopoietic stem cell transplantation
ovarian function
ovarian insufficiency
pregnancy
reduced-intensity conditioning
2016-11-03 16:10:08
Dataset
https://tandf.figshare.com/articles/dataset/Ovarian_insufficiency_following_allogeneic_hematopoietic_stem_cell_transplantation/4203381
<p>Ovarian insufficiency is a serious complication for young women who undergo hematopoietic stem cell transplantation (HSCT). Reduced-intensity conditioning (RIC) has been utilized more widely due to its reduced toxicity; however, there is a lack of data concerning ovarian function after HSCT with RIC. We investigated the ovarian function in patients who received HSCT with RIC, compared to those who received myeloablative conditioning (MAC). The records of 69 female patients who received allogeneic HSCT at the institution under 40 years of age at transplantation from 1991 to 2012 were retrospectively analyzed. Prevalence of ovarian insufficiency was significantly lower in patients conditioned with RIC than in those conditioned with MAC (4/27 = 14.8% for RIC and 36/42 = 85.7% for MAC, <i>p</i> < 0.0001). A younger age at HSCT was associated with a lower risk of ovarian insufficiency. Among the 40 patients with ovarian insufficiency, four patients recovered ovarian function, and two conceived following hormone-replacement therapy (HRT). A higher serum E2 level prior to HRT was a significant predictor for the restoration of ovarian function (<i>p</i> = 0.0028). In conclusion, RIC was significantly less toxic to ovarian function compared with MAC. HSCT-associated ovarian insufficiency is not irreversible, and a higher E2 level may predict the restoration of ovarian function.</p>