Expected and actual adverse drug-drug interactions in elderly patients accessing the emergency department: data from the ANCESTRAL-ED study
A. Marino
A. Capogrosso-Sansone
M. Tuccori
G. Bini
V. Calsolaro
S. Mantarro
I. Convertino
G. Pasqualetti
E. Orsitto
M. Santini
F. Monzani
C. Blandizzi
10.6084/m9.figshare.4249151.v1
https://tandf.figshare.com/articles/journal_contribution/Expected_and_actual_adverse_drug-drug_interactions_in_elderly_patients_accessing_the_emergency_department_data_from_the_ANCESTRAL-ED_study/4249151
<p><b>Objective</b>: This study was aimed at evaluating the frequency and describing the adverse drug-drug interactions (DDIs) recorded among elderly patients accessing the emergency department (ED).</p> <p><b>Methods</b>: Patients aged ≥65 years, accessing the ED of Pisa University Hospital (Italy) from 1 January 2015 to 31 December 2015 within the ANCESTRAL-ED program, were included in this study. ‘Expected’ DDIs were assessed using Thomson Micromedex®. Each ED admission (discharge diagnosis) consistent with the signs and symptoms of an expected DDI for each patient was classified as an ‘actual’ DDI.</p> <p><b>Results</b>: Throughout the study period, 3473 patients (3812 ED admissions, 58% females, mean age: 80.3) were recorded. The total number of expected DDIs was 12,578 (67 contraindicated; 3334 major; 8878 moderate; 299 minor) detected in 2147 (62%) patients. Overall 464 expected DDIs were found to be consistent with the ED admission in 194 patients (representing 9% of patients with expected DDIs).</p> <p><b>Conclusions</b>: More than one half of elderly patients admitted to ED presented at least one expected DDI at the time of ED presentation. However, 9% of the expected DDIs were identified as actual DDIs, based on the consistency of the expected event with the ED discharge diagnosis.</p>
2016-11-23 06:58:00
Elderly patients
emergency department
drug-drug interactions
adverse drug reactions