10.6084/m9.figshare.4296455.v1
Christina Andreou
Christina
Andreou
Julia Kleinert
Julia
Kleinert
Saskia Steinmann
Saskia
Steinmann
Ulrike Fuger
Ulrike
Fuger
Gregor Leicht
Gregor
Leicht
Christoph Mulert
Christoph
Mulert
Oscillatory responses to reward processing in borderline personality disorder
Taylor & Francis Group
2016
feedback-related negativity
event related potentials
impulsivity
anterior cingulate cortex
orbitofrontal cortex
2016-12-08 18:16:34
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Oscillatory_responses_to_reward_processing_in_borderline_personality_disorder/4296455
<p><i>Objectives.</i> Previous electrophysiological studies have confirmed impaired reward processing in patients with BPD. However, it is not clear which aspects of reward processing are affected and which brain regions are involved. The present study investigated both evoked and induced event-related oscillations (EROs) to feedback events (thought to represent different aspects of feedback processing), and used source localization (sLORETA) to assess activity in two areas known to contribute to reward processing, the dorsomedial prefrontal/anterior cingulate cortex (dmPFC/ACC) and the orbitofrontal cortex (OFC). <i>Methods.</i> Eighteen patients with BPD and 22 healthy controls performed a gambling task, while 64-channel electroencephalographic activity was recorded. Evoked and induced theta and high-beta band EROs as well as activity in the two regions of interest were investigated depending on the valence and magnitude of feedback events. <i>Results.</i> Theta-band responses to negative feedback were reduced in BPD, an effect that involved only evoked responses and the dmPFC/ ACC region, and was associated with trait impulsivity in patients. sLORETA analyses revealed disturbed evoked responses depending on feedback magnitude in the theta (OFC) and high-beta (dmPFC/ACC and OFC) frequency range. <i>Conclusions.</i> The results indicate multiple dysfunctions of feedback processing in patients with BPD, implicating several distinct subsets of reward-processing mechanisms.</p>