10.6084/m9.figshare.4541104.v2
Dattatray Survase
Dattatray
Survase
Babasaheb Bandgar
Babasaheb
Bandgar
Vasant Helavi
Vasant
Helavi
Polyethylene glycol-promoted synthesis of pyrimido[1,2-<i>a</i>]benzimidazole and pyrano[2,3-<i>c</i>]pyrazole derivatives in water
Taylor & Francis Group
2017
Catalyst-free synthesis
pyrimido[1,2-a]benzimidazole
PEG-Water
pyrano[2,3-c]pyrazole
2017-03-17 16:22:09
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Polyethylene_Glycol_Promoted_Synthesis_of_Pyrimido_1_2-a_benzimidazole_and_Pyrano_2_3-c_pyrazole_Derivatives_in_Water/4541104
<p>Synthesis of pyrimido[1,2-<i>a</i>]benzimidazole and pyrano[2,3-<i>c</i>]pyrazole derivatives were achieved using polyethylene glycol (PEG-400) as promoting reaction medium in water under catalyst-free conditions at reflux and room temperature, respectively. The structure of pyrimido[1,2-<i>a</i>]benzimidazole was confirmed using <sup>1</sup>H NMR, <sup>13</sup>C NMR, DEPT, and HMBC experiments. The promising points for the present methodology are efficiency, generality, high yield, short reaction time, cleaner reaction profile, ease of product isolation, simplicity, potential of recycling reaction medium, and finally agreement with green chemistry protocols.</p>