%0 Journal Article %A Hong, Xian-Lan %A Zeng, Mao-Hua %A Liu, Li-Juan %A Ye, Xiu-Li %A Yi, Dao-Sheng %D 2017 %T Synthesis, characterization and in vitro antitumor behavior of a vanadium(V) complex with 4′-(3-methoxyphenyl)-2,2′:6′2″-terpyridine %U https://tandf.figshare.com/articles/journal_contribution/Synthesis_characterization_and_i_in_vitro_i_antitumor_behavior_of_a_vanadium_V_complex_with_4_-_3-methoxyphenyl_-2_2_6_2_-terpyridine/4620337 %R 10.6084/m9.figshare.4620337.v2 %2 https://tandf.figshare.com/ndownloader/files/7515718 %K Vanadium complex %K cytotoxicity %K mitochondrial membrane potential %K apoptotic mechanism %X

A dioxovanadium(V) complex, [VO2(moptpy)](ClO4) (1, moptpy = 4′-(3-methoxyphenyl)2,2′:6′2″-terpyridine), was synthesized and characterized by elemental analysis, ESI-MS, UV–vis, IR, and 1H, 13C, and 51V NMR. The cytotoxicity in vitro of 1 was evaluated against cancer cell lines HepG-2 (hepatocellular carcinoma), SGC-7901 (gastric carcinoma), SiHa (cervical cancer), BEL-7402 (hepatocellular), and rat PC-12 (pheochromocytoma) by the MTT method. The results demonstrated that 1 exhibits superior anticancer activity in vitro with much lower values of 50% inhibitive concentration (IC50) against the selected cell lines than cisplatin, and 1 shows the highest cytotoxic activity toward SGC-7901 cells (IC50 = 1.3 ± 0.1 μM) among the selected cell lines. A series of cellular morphological and staining experiments were carried out, and the results indicated that 1 can effectively induce apoptosis of SGC-7901 cells through a ROS-mediated mitochondrial dysfunction pathway. In addition, cellular incorporation and cell cycle analysis were also performed, and it was concluded from the experimental observations that 1 can efficiently enter into the cell nuclei, and the complex inhibits cell growth in SGC-7901 cell at G0/G1 phase.

%I Taylor & Francis