A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity S. N. Suresh Aravinda K. Chavalmane Vidyadhara DJ Haorei Yarreiphang Shashank Rai Abhik Paul James P. Clement Phalguni Anand Alladi Ravi Manjithaya 10.6084/m9.figshare.4793893.v1 https://tandf.figshare.com/articles/journal_contribution/A_novel_autophagy_modulator_6-Bio_ameliorates_SNCA_-synuclein_toxicity/4793893 <p>Parkinson disease (PD) is a life-threatening neurodegenerative movement disorder with unmet therapeutic intervention. We have identified a small molecule autophagy modulator, 6-Bio that shows clearance of toxic SNCA/α-synuclein (a protein implicated in synucleopathies) aggregates in yeast and mammalian cell lines. 6-Bio induces autophagy and dramatically enhances autolysosome formation resulting in SNCA degradation. Importantly, neuroprotective function of 6-Bio as envisaged by immunohistology and behavior analyses in a preclinical model of PD where it induces autophagy in dopaminergic (DAergic) neurons of mice midbrain to clear toxic protein aggregates suggesting that it could be a potential therapeutic candidate for protein conformational disorders.</p> 2017-03-28 15:12:24 6-Bio autolysosomes autophagy high-throughput screening MPTP neurodegeneration, SNCA TH