A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity
S. N. Suresh
Aravinda K. Chavalmane
Vidyadhara DJ
Haorei Yarreiphang
Shashank Rai
Abhik Paul
James P. Clement
Phalguni Anand Alladi
Ravi Manjithaya
10.6084/m9.figshare.4793893.v1
https://tandf.figshare.com/articles/journal_contribution/A_novel_autophagy_modulator_6-Bio_ameliorates_SNCA_-synuclein_toxicity/4793893
<p>Parkinson disease (PD) is a life-threatening neurodegenerative movement disorder with unmet therapeutic intervention. We have identified a small molecule autophagy modulator, 6-Bio that shows clearance of toxic SNCA/α-synuclein (a protein implicated in synucleopathies) aggregates in yeast and mammalian cell lines. 6-Bio induces autophagy and dramatically enhances autolysosome formation resulting in SNCA degradation. Importantly, neuroprotective function of 6-Bio as envisaged by immunohistology and behavior analyses in a preclinical model of PD where it induces autophagy in dopaminergic (DAergic) neurons of mice midbrain to clear toxic protein aggregates suggesting that it could be a potential therapeutic candidate for protein conformational disorders.</p>
2017-03-28 15:12:24
6-Bio
autolysosomes
autophagy
high-throughput screening
MPTP
neurodegeneration, SNCA
TH