10.6084/m9.figshare.4873136.v2
Shaoyu Liu
Shaoyu
Liu
Xiaolan Tang
Xiaolan
Tang
Dahong Nie
Dahong
Nie
Shende Jiang
Shende
Jiang
Ganghua Tang
Ganghua
Tang
Efficient synthesis of (2<i>S</i>)-<i>tert</i>-butyl 2-(2-bromopropanamido)-5-oxo-5-(tritylamino)pentanoate as a precursor of PET radiotracer [<sup>18</sup>F]FPGLN
Taylor & Francis Group
2017
Glutamine derivatives
new precursor
positron emission tomography
radiotracer
2017-06-01 14:46:17
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Efficient_synthesis_of_2S_-_i_tert_i_-butyl_2-_2-bromopropanamido_-5-oxo-5-_tritylamino_pentanoate_as_a_precursor_of_PET_radiotracer_sup_18_sup_F_FPGLN/4873136
<p>This study describes a convenient protocol for the synthesis of (2<i>S</i>)-<i>tert</i>-butyl 2-(2-bromopropanamido)-5-oxo-5-(tritylamino)pentanoate, which can serve as an appropriate precursor of (2<i>S</i>)-5-amino-2-(2-[<sup>18</sup>F]fluoropropanamido)-5-oxopentanoic acid (<i>N</i>-(2-[<sup>18</sup>F]fluoropropionyl)-L-glutamine, [<sup>18</sup>F]FPGLN) for tumor positron emission tomography imaging. Five-step synthesis starting from L-glutamine provided the desired precursor with high yields. In addition, a simple method for the preparation of [<sup>18</sup>F]FPGLN from this easily available precursor was developed using a two-step <sup>18</sup>F-labeling strategy.</p>