%0 Journal Article %A Liu, Shaoyu %A Tang, Xiaolan %A Nie, Dahong %A Jiang, Shende %A Tang, Ganghua %D 2017 %T Efficient synthesis of (2S)-tert-butyl 2-(2-bromopropanamido)-5-oxo-5-(tritylamino)pentanoate as a precursor of PET radiotracer [18F]FPGLN %U https://tandf.figshare.com/articles/journal_contribution/Efficient_synthesis_of_2S_-_i_tert_i_-butyl_2-_2-bromopropanamido_-5-oxo-5-_tritylamino_pentanoate_as_a_precursor_of_PET_radiotracer_sup_18_sup_F_FPGLN/4873136 %R 10.6084/m9.figshare.4873136.v2 %2 https://tandf.figshare.com/ndownloader/files/8137784 %K Glutamine derivatives %K new precursor %K positron emission tomography %K radiotracer %X

This study describes a convenient protocol for the synthesis of (2S)-tert-butyl 2-(2-bromopropanamido)-5-oxo-5-(tritylamino)pentanoate, which can serve as an appropriate precursor of (2S)-5-amino-2-(2-[18F]fluoropropanamido)-5-oxopentanoic acid (N-(2-[18F]fluoropropionyl)-L-glutamine, [18F]FPGLN) for tumor positron emission tomography imaging. Five-step synthesis starting from L-glutamine provided the desired precursor with high yields. In addition, a simple method for the preparation of [18F]FPGLN from this easily available precursor was developed using a two-step 18F-labeling strategy.

%I Taylor & Francis