First report of the <i>in vitro</i> antileishmanial properties of extremophile plants from the Algarve Coast
Marta Oliveira
Maria João Rodrigues
Catarina Pereira
Rubens Lima do Monte Neto
Policarpo Ademar Santos Junior
Nuno da Rosa Neng
José Manuel Florêncio Nogueira
João Varela
Luísa Barreira
Luísa Custódio
10.6084/m9.figshare.5001872
https://tandf.figshare.com/articles/journal_contribution/First_report_of_the_i_in_vitro_i_antileishmanial_properties_of_extremophile_plants_from_the_Algarve_Coast/5001872
<p>This work reports for the first time the <i>in vitro</i> anti <i>Leishmania infantum</i> activity of acetone and dichloromethane (DCM) extracts from 25 extremophile plants from Southern Portugal. DCM extracts from <i>Inula chritmoides</i> and <i>Spergularia rubra</i> were active against axenic promastigotes and intracellular amastigotes, had anti-inflammatory properties on lipopolysaccharide (LPS)-stimulated macrophages, inhibited acetylcholinesterase and had no haemolytic activity on human erythrocytes. Eleven phenolics were identified by high-performance liquid chromatography with diode-array detection (HPLC-DAD) in <i>I. crithmoides</i> and one phenolic in <i>S. rubra</i>. Isolation and identification of the active molecules is in progress.</p>
2017-05-12 06:52:55
Antiparasitic
halophytes
Inula chritmoides
Leishmania infantum
neglected tropical diseases
Spergularia rubra
visceral leishmaniasis