First report of the <i>in vitro</i> antileishmanial properties of extremophile plants from the Algarve Coast Marta Oliveira Maria João Rodrigues Catarina Pereira Rubens Lima do Monte Neto Policarpo Ademar Santos Junior Nuno da Rosa Neng José Manuel Florêncio Nogueira João Varela Luísa Barreira Luísa Custódio 10.6084/m9.figshare.5001872 https://tandf.figshare.com/articles/journal_contribution/First_report_of_the_i_in_vitro_i_antileishmanial_properties_of_extremophile_plants_from_the_Algarve_Coast/5001872 <p>This work reports for the first time the <i>in vitro</i> anti <i>Leishmania infantum</i> activity of acetone and dichloromethane (DCM) extracts from 25 extremophile plants from Southern Portugal. DCM extracts from <i>Inula chritmoides</i> and <i>Spergularia rubra</i> were active against axenic promastigotes and intracellular amastigotes, had anti-inflammatory properties on lipopolysaccharide (LPS)-stimulated macrophages, inhibited acetylcholinesterase and had no haemolytic activity on human erythrocytes. Eleven phenolics were identified by high-performance liquid chromatography with diode-array detection (HPLC-DAD) in <i>I. crithmoides</i> and one phenolic in <i>S. rubra</i>. Isolation and identification of the active molecules is in progress.</p> 2017-05-12 06:52:55 Antiparasitic halophytes Inula chritmoides Leishmania infantum neglected tropical diseases Spergularia rubra visceral leishmaniasis