10.6084/m9.figshare.5097556
MD. Ashraf
Ashraf
Javed Abrar Farooqi
Javed Abrar
Farooqi
Kalim Javed
Kalim
Javed
Evaluation of macrophage injury and activation by amphotericin B-loaded polymeric nanoparticles
Taylor & Francis Group
2017
Amphotericin B
drug delivery
macrophage
NIPAM
phagocytosis
NIPAM: N-isopropylacrylamide
AA: acrylic acid
VP: vinyl pyrrolidone
AmB: amphotericin B
MBA: N,N-methylene-bis-acrylamide
ROS: reactive oxygen species
SOD: superoxide dismutase
DSC: differential scanning calorimeter
TGA: thermogravimetric analysis
DNA: deoxy ribonucleic acid
IFN-γ, type II interferon
TGF: transforming growth factor
2017-08-11 14:20:48
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Evaluation_of_Macrophage_Injury_and_Activation_by_Amphotericin_B_Loaded_Polymeric_Nanoparticles/5097556
<p>The objectives of present work were to prepare water soluble nanoformulation of amphotericin B by radical polymerization using <i>N</i>-isopropylacrylamide–acrylic acid and vinyl pyrrolidone for targeted delivery and minimized toxicity in mild experimental conditions with relatively narrow size distribution. The prepared formulations were extensively characterized in terms of size, morphology, thermal stability, drug loading and toxicity. The results demonstrates that the prepared nanoformulation have the potential to deliver amphotericin B with increased bioavailability and cellular uptake.</p>