Synthesis of 3-acylated indoles through iron-catalyzed oxidative coupling of indoles with α-amino carbonyl compounds
Niannian Yi
Jinxia Li
Hao Zhang
Ruijia Wang
Jun Jiang
Wei Deng
Zebing Zeng
Jiannan Xiang
10.6084/m9.figshare.5303314
https://tandf.figshare.com/articles/journal_contribution/Synthesis_of_3-acylated_indoles_via_iron-catalyzed_oxidative_coupling_of_indoles_with_-amino_carbonyl_compounds/5303314
<p>A novel iron-catalyzed oxidative coupling of indoles with α-amino carbonyl compounds has been developed. The transformation provides an attractive approach to the synthesis of 3-acylindoles, with the advantages of easily available starting materials and high functional group tolerance. Furthermore, control experiments imply that a radical process maybe involved in this reaction.</p>
2017-10-05 14:36:53
3-Acylindoles
α-amino carbonyl compound
iron
oxidative coupling