Design, synthesis and biological evaluation of chrysin benzimidazole derivatives as potential anticancer agents Zhe Wang Xiangping Deng Shujuan Xiong Runde Xiong Juan Liu Liu Zou Xiaoyong Lei Xuan Cao Zhizhong Xie Yanming Chen Yunmei Liu Xing Zheng Guotao Tang 10.6084/m9.figshare.5531782.v1 https://tandf.figshare.com/articles/journal_contribution/Design_synthesis_and_biological_evaluation_of_chrysin_benzimidazole_derivatives_as_potential_anticancer_agents/5531782 <p>A series of chrysin benzimidazole derivatives were synthesised and evaluated for their anticancer activity in the search for potential anticancer agents. Among them, compound <b>18</b> displayed the most potent anti-proliferative activity against MFC cells with IC<sub>50</sub> values of 25.72 ± 3.95 μM. The flow cytometry results displayed that compound <b>18</b> induced apoptosis of MFC cells in a dose-dependent manner and caused the cell cycle to be arrested in the G0/G1 phase. Furthermore, the preliminary anticancer activity <i>in vivo</i> was also studied in tumour-bearing mice, and the compound <b>18</b> exerted good inhibition effect on tumour growth. These results suggested that compound <b>18</b> had good anticancer activity, which could be a potential anticancer agent after further optimisation and evaluation.</p> 2017-10-24 09:44:54 Chrysin benzimidazole synthesis anticancer