%0 Journal Article %A Wang, Zhe %A Deng, Xiangping %A Xiong, Shujuan %A Xiong, Runde %A Liu, Juan %A Zou, Liu %A Lei, Xiaoyong %A Cao, Xuan %A Xie, Zhizhong %A Chen, Yanming %A Liu, Yunmei %A Zheng, Xing %A Tang, Guotao %D 2017 %T Design, synthesis and biological evaluation of chrysin benzimidazole derivatives as potential anticancer agents %U https://tandf.figshare.com/articles/journal_contribution/Design_synthesis_and_biological_evaluation_of_chrysin_benzimidazole_derivatives_as_potential_anticancer_agents/5531782 %R 10.6084/m9.figshare.5531782.v1 %2 https://tandf.figshare.com/ndownloader/files/9577579 %K Chrysin %K benzimidazole %K synthesis %K anticancer %X

A series of chrysin benzimidazole derivatives were synthesised and evaluated for their anticancer activity in the search for potential anticancer agents. Among them, compound 18 displayed the most potent anti-proliferative activity against MFC cells with IC50 values of 25.72 ± 3.95 μM. The flow cytometry results displayed that compound 18 induced apoptosis of MFC cells in a dose-dependent manner and caused the cell cycle to be arrested in the G0/G1 phase. Furthermore, the preliminary anticancer activity in vivo was also studied in tumour-bearing mice, and the compound 18 exerted good inhibition effect on tumour growth. These results suggested that compound 18 had good anticancer activity, which could be a potential anticancer agent after further optimisation and evaluation.

%I Taylor & Francis