%0 Journal Article %A Zheng, Liang %A Wang, Xiangping %A Tao, Qin %A Liang, Shuhui %A Wang, Biaoluo %A Luo, Hui %A Zhang, Rongchun %A Zheng, Liyue %A Yang, Shengye %A Chen, Jie %A Pan, Yanglin %A Guo, Xuegang %D 2017 %T Different pattern of risk factors for post-ERCP pancreatitis in patients with biliary stricture %U https://tandf.figshare.com/articles/journal_contribution/Different_pattern_of_risk_factors_for_post-ERCP_pancreatitis_in_patients_with_biliary_stricture/5584360 %R 10.6084/m9.figshare.5584360.v1 %2 https://tandf.figshare.com/ndownloader/files/9710899 %K Post-ERCP pancreatitis %K risk factors %K biliary stricture %K duodenal stenosis %K hilar stricture %X

Objective: To identify possible risk factors associated with post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in biliary stricture (BS), common bile duct stone (CBDS) and unselected patients.

Materials and methods: Consecutive ERCP patients with native papilla from January 2010 to December 2014 in Xijing Hospital were eligible. Patient-related and procedure-related parameters were collected retrospectively. The primary outcome was PEP. Univariate and multivariate logistic regression were used for data analysis.

Results: Totally 3133 unselected patients were included. 695 (22.2%) had BS alone and 1893 (60.4%) had CBDS alone. PEP incidence was higher in BS group compared with CBDS group (6.8% vs. 3.8%, p = .001). Among patient-related factors, duodenal stenosis (OR, 2.74; 95%CI, 1.14–6.59) and hilar stricture (OR, 2.59; 95%CI, 1.41–4.77) were found to be independently associated with PEP in BS group. While female gender (OR, 2.11; 95%CI, 1.20–3.73) and normal total bilirubin (OR, 1.93; 95%CI, 1.13–3.32) were related to PEP in CBDS group. Among procedure-related factors, cannulation time ≥ 5 min (OR, 2.38; 95%CI, 1.06–5.33) and precut (OR, 3.20; 95%CI, 1.35–7.59) was respectively the only independent risk factor for PEP in BS and CBDS group.

Conclusions: Patients with BS and CBDS had different patterns of patient-related and procedure-related risk factors for PEP. The prophylaxis of PEP may need to be individualized based on different indications.

%I Taylor & Francis