%0 Journal Article %A Tian, Han-Wen %A Pan, Yu-Chen %A Guo, Dong-Sheng %D 2017 %T Assembly-enhanced molecular recognition of calix[6]arene %U https://tandf.figshare.com/articles/journal_contribution/Assembly-enhanced_molecular_recognition_of_calix_6_arene/5697319 %R 10.6084/m9.figshare.5697319.v1 %2 https://tandf.figshare.com/ndownloader/files/9981340 %K Molecular recognition %K self-assembly %K calixarene %K conformation %K liposome %X

We comparatively investigated the molecular recognition of the amphiphilic derivatives of p-sulfonatocalix[n]arenes (SCnA-Rs, n = 4 and 6) both in aqueous solution and at the interface of liposome. When the recognition events transfer from aqueous solution to the self-assembled interface, the binding capability of SC6A-R increases drastically, but not for SC4A-R. It originates from the conformational regulation that the complicated conformation of SC6A-R in aqueous solution was immobilized to the cone shape upon embedding SC6A-R into the liposome. The resulting cone shape is privileged to accommodate guests into its cavity. Such an assembly-enhanced molecular recognition strategy could be transferable to other macrocyclic, acyclic, artificial, and natural receptors with conformational flexibility.

%I Taylor & Francis