10.6084/m9.figshare.5712280.v1
Kelly J. Valentini
Kelly J.
Valentini
C. Austin Pickens
C. Austin
Pickens
Jason A. Wiesinger
Jason A.
Wiesinger
Jenifer I. Fenton
Jenifer
I. Fenton
The effect of fish oil supplementation on brain DHA and EPA content and fatty acid profile in mice
Taylor & Francis Group
2017
Brain
phospholipid
DHA
EPA
desaturase
fatty acid
2017-12-18 18:16:20
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/The_effect_of_fish_oil_supplementation_on_brain_DHA_and_EPA_content_and_fatty_acid_profile_in_mice/5712280
<p>Supplementation with omega-3 (n-3) fatty acids may improve cognitive performance and protect against cognitive decline. However, changes in brain phospholipid fatty acid composition after supplementation with n-3 fatty acids are poorly described. The purpose of this study was to feed increasing n-3 fatty acids and characterise the changes in brain phospholipid fatty acid composition and correlate the changes with red blood cells (RBCs) and plasma in mice. Increasing dietary docosahexaenoic (DHA) and eicosapentaenoic acid (EPA) did not alter brain DHA. Brain EPA increased and total n-6 polyunsaturated fatty acids decreased across treatment groups, and correlated with fatty acid changes in the RBC (<i>r</i> > 0.7). Brain <i>cis</i>-monounsaturated fatty acids oleic and nervonic acid (<i>p</i> < .01) and saturated fatty acids arachidic, behenic, and lignoceric acid (<i>p</i> < .05) also increased. These brain fatty acid changes upon increasing n-3 intake should be further investigated to determine their effects on cognition and neurodegenerative disease.</p>