%0 Generic %A Chen, Xiaoning %A Li, Qianxi %A Wang, Xiaoye %A Chen, Jing %A Lv, Wen %A Shi, Bin %A Wang, Hong %A Luo, Jianru %A Li, Jian %D 2018 %T Bleeding pattern difference between levonorgestrel intrauterine system and copper intrauterine devices inserted immediately post-abortion: a multicenter, prospective, observational cohort study in Chinese women %U https://tandf.figshare.com/articles/dataset/Bleeding_pattern_difference_between_levonorgestrel-intrauterine_system_and_copper-intrauterine_devices_inserted_immediately_post-abortion_a_multicenter_prospective_observational_cohort_study_in_Chinese_women/5755851 %R 10.6084/m9.figshare.5755851.v2 %2 https://tandf.figshare.com/ndownloader/files/10140018 %2 https://tandf.figshare.com/ndownloader/files/10140021 %2 https://tandf.figshare.com/ndownloader/files/10140024 %2 https://tandf.figshare.com/ndownloader/files/10140027 %K Levonorgestrel-releasing intrauterine system %K bleeding patterns %K dysmenorrhea severity %K satisfaction %X

Background: To describe the bleeding pattern (primary outcome), side effects, treatment satisfaction and 6 month continuity rates associated with the 52 mg levonorgestrel intrauterine system (LNG-IUS) and the copper intrauterine device (Cu-IUD) inserted immediately after abortion.

Methods: This multicenter, prospective, observational cohort study enrolled healthy women (aged ≥18 years) inserted with LNG-IUS or Cu-IUD immediately after first-trimester surgical abortion and followed up to 6 months. Bleeding pattern was obtained through daily patient bleeding diaries.

Results: From 2013 to 2014, we enrolled 512 women (LNG-IUS = 312 [median age: 32.0 years] and Cu-IUD = 200 [median age: 30.0 years]) from nine Chinese centers. LNG-IUS resulted in a significantly lower number of bleeding/spotting days in the second 90 day reference period compared with Cu-IUD (median 14.5 vs. 18.0 days, p < .0001). Amenorrhea rate (no bleeding/spotting day in the second 90 day reference period) and no menstrual bleeding rate (absence of bleeding days in the second 90 day reference period) were significantly higher in LNG-IUS compared to Cu-IUD (13.9% vs. 0% and 39.5% vs. 0%; p < .001 for all). No dysmenorrhea was higher at the last follow-up in LNG-IUS users than Cu-IUD users (81.2% vs. 76%; p = .0047). Both treatments had a high satisfaction rate among women at both the follow-up visits, and the majority of them continued with the treatment. The rates of adverse events (e.g. oligomenorrhea, amenorrhea) in the LNG-IUS and Cu-IUD groups were 77.2% and 44.5% (p < .0001), respectively.

Conclusion: LNG-IUS post-abortion shows better bleeding patterns, and reduced dysmenorrhea and bleeding amount, but with a similar safety profile compared with Cu-IUD.

ClinicalTrials.gov identifier: NCT01958684

%I Taylor & Francis