10.6084/m9.figshare.5831094.v1 Bing Wang Bing Wang Teng Liu Teng Liu Zhongyu Wu Zhongyu Wu Lei Zhang Lei Zhang Jie Sun Jie Sun Xiaojing Wang Xiaojing Wang Synthesis and biological evaluation of stilbene derivatives coupled to NO donors as potential antidiabetic agents Taylor & Francis Group 2018 α-Glucosidase inhibitor antidiabetic AGEs formation inhibitor stilbene nitric oxide donor 2018-01-29 08:55:48 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Synthesis_and_biological_evaluation_of_stilbene_derivatives_coupled_to_NO_donors_as_potential_antidiabetic_agents/5831094 <p>The work is focused on the design of drugs that prevent and treat diabetes and its complications. A novel class of stilbene derivatives were prepared by coupling NO donors of alkyl nitrate and were fully characterised by NMR and other techniques. These compounds were tested <i>in vitro</i> activity, including α-glucosidase inhibitory activity, aldose reductase (AR) inhibitory activity and advanced glycation end products (AGEs) formation inhibitory activity. A class of modified compounds could play a significant effect for treatment of diabetic complications. Target compounds <b>3e</b> and <b>7c</b> offered a potential drug design concept for the development of therapeutic or preventive agents for diabetes and its complications.</p>