10.6084/m9.figshare.5831094.v1
Bing Wang
Bing
Wang
Teng Liu
Teng
Liu
Zhongyu Wu
Zhongyu
Wu
Lei Zhang
Lei
Zhang
Jie Sun
Jie
Sun
Xiaojing Wang
Xiaojing
Wang
Synthesis and biological evaluation of stilbene derivatives coupled to NO donors as potential antidiabetic agents
Taylor & Francis Group
2018
α-Glucosidase inhibitor
antidiabetic
AGEs formation inhibitor
stilbene
nitric oxide donor
2018-01-29 08:55:48
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Synthesis_and_biological_evaluation_of_stilbene_derivatives_coupled_to_NO_donors_as_potential_antidiabetic_agents/5831094
<p>The work is focused on the design of drugs that prevent and treat diabetes and its complications. A novel class of stilbene derivatives were prepared by coupling NO donors of alkyl nitrate and were fully characterised by NMR and other techniques. These compounds were tested <i>in vitro</i> activity, including α-glucosidase inhibitory activity, aldose reductase (AR) inhibitory activity and advanced glycation end products (AGEs) formation inhibitory activity. A class of modified compounds could play a significant effect for treatment of diabetic complications. Target compounds <b>3e</b> and <b>7c</b> offered a potential drug design concept for the development of therapeutic or preventive agents for diabetes and its complications.</p>