Expeditious synthesis of 9-allenylpurines <i>via</i> cesium carbonate catalyzed isomerization of 9-alkynylpurines
Mingwu Yu
Xiguang Liu
Qingsong Jiang
Hongguang Du
10.6084/m9.figshare.5851863.v1
https://tandf.figshare.com/articles/journal_contribution/Expeditious_synthesis_of_9-allenylpurines_i_via_i_cesium_carbonate_catalyzed_isomerization_of_9-alkynylpurines/5851863
<p>An expeditious and convenient method to synthesize 9-allenylpurines <i>via</i> cesium carbonate catalyzed isomerization of 9-alkynylpurines has been successfully developed. The reactions proceeded rapidly under the base conditions and formed the desired products in good to excellent yields. The method was suitable with a broad substrate scope and proceeded well even on a multgram-scale. The obtained 9-allenylpurines were successfully applied to prepare various potential bioactive 9-acyclic nucleosides with high regioselectivity promoted by AgNO<sub>3</sub>.</p>
2018-02-02 21:29:54
9-Allenylpurines
9-Alkynylpurines
Cesium carbonate
Isomerization
9-Acyclic nucleosides